American Airlines flights from Des Moines to Mexico
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1 Adult, Economy class
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today
today
Popular flights with American Airlines
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*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.
Find more Des Moines to Mexico deals
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Des Moines (DSM)to
Cancun (CUN)
09/09/25 - 09/16/25
Round trip
Economy
from
$397Fare subject to changes
Updated: 7 hours ago
Des Moines (DSM)to
Cabo San Lucas (SJD)
08/19/25 - 08/26/25
Round trip
Economy
from
$446Fare subject to changes
Updated: 6 hours ago
Des Moines (DSM)to
Puerto Vallarta (PVR)
08/19/25 - 08/26/25
Round trip
Economy
from
$446Fare subject to changes
Updated: 10 hours ago
Des Moines (DSM)to
Mexico City (MEX)
10/01/25 - 10/08/25
Round trip
Economy
from
$540Fare subject to changes
Updated: 1 hour ago
Des Moines (DSM)to
Guadalajara (GDL)
08/05/25 - 08/12/25
Round trip
Economy
from
$538Fare subject to changes
Updated: 9 hours ago
Des Moines (DSM)to
Cozumel (CZM)
07/16/25 - 07/23/25
Round trip
Economy
from
$495Fare subject to changes
Updated: 12 hours ago
*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.