American Airlines flights to Des Moines from $159*

Popular flights to Des Moines on American Airlines

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*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

American Airlines flights to Des Moines from **Flights.FromLowestPrice***

Find deals on flights to Des Moines

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Phoenix (PHX)to

Des Moines (DSM)
07/08/25 - 07/15/25

Round trip

Economy

from
$189Fare subject to changes
Updated: 10 hours ago

Dallas (DFW)to

Des Moines (DSM)
08/19/25 - 08/20/25

Round trip

Economy

from
$200Fare subject to changes
Updated: 7 hours ago

Washington, D.C. (DCA)to

Des Moines (DSM)
08/13/25 - 08/20/25

Round trip

Economy

from
$285Fare subject to changes
Updated: 11 hours ago

Chicago (ORD)to

Des Moines (DSM)
08/22/25 - 08/24/25

Round trip

Economy

from
$169Fare subject to changes
Updated: 14 hours ago

Charlotte (CLT)to

Des Moines (DSM)
08/05/25 - 08/12/25

Round trip

Economy

from
$305Fare subject to changes
Updated: 1 hour ago

Philadelphia (PHL)to

Des Moines (DSM)
07/15/25 - 07/22/25

Round trip

Economy

from
$225Fare subject to changes
Updated: 1 hour ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Des Moines routes with American Airlines