American Airlines flights to Panama City from $217*

Popular flights to Panama City on American Airlines

American Airlines offers flights to Panama City (ECP) from cities across the U.S. Nonstop and connecting options are available depending on the route and travel dates, with schedules and fares that vary throughout the year.

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  • Chicago (ORD)to

    Panama City (ECP)
    06/23/26 - 06/30/26
    from
    $347Fare subject to changes
    Updated: 9 hours ago
    Round trip
    Economy

    Phoenix (PHX)to

    Panama City (ECP)
    08/12/26 - 08/19/26
    from
    $397Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

    Austin (AUS)to

    Panama City (ECP)
    08/12/26 - 08/19/26
    from
    $217Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

    Saint Louis (STL)to

    Panama City (ECP)
    07/10/26 - 07/17/26
    from
    $315Fare subject to changes
    Updated: 8 hours ago
    Round trip
    Economy

  • Los Angeles (LAX)to

    Panama City (ECP)
    08/04/26 - 08/11/26
    from
    $403Fare subject to changes
    Updated: 8 hours ago
    Round trip
    Economy

    Tulsa (TUL)to

    Panama City (ECP)
    08/12/26 - 08/19/26
    from
    $341Fare subject to changes
    Updated: 9 hours ago
    Round trip
    Economy

    Oklahoma City (OKC)to

    Panama City (ECP)
    07/04/26 - 07/11/26
    from
    $357Fare subject to changes
    Updated: 8 hours ago
    Round trip
    Economy

    Columbus (CMH)to

    Panama City (ECP)
    08/04/26 - 08/11/26
    from
    $387Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

  • Nashville (BNA)to

    Panama City (ECP)
    07/03/26 - 07/10/26
    from
    $301Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

    Boston (BOS)to

    Panama City (ECP)
    06/08/26 - 06/15/26
    from
    $217Fare subject to changes
    Updated: 6 hours ago
    Round trip
    Economy

    Pittsburgh (PIT)to

    Panama City (ECP)
    08/15/26 - 08/22/26
    from
    $373Fare subject to changes
    Updated: 2 hours ago
    Round trip
    Economy

    Baltimore (BWI)to

    Panama City (ECP)
    07/06/26 - 07/13/26
    from
    $327Fare subject to changes
    Updated: 8 hours ago
    Round trip
    Economy

  • Salt Lake City (SLC)to

    Panama City (ECP)
    08/04/26 - 08/11/26
    from
    $403Fare subject to changes
    Updated: 6 hours ago
    Round trip
    Economy

    New York (NYC)to

    Panama City (ECP)
    07/07/26 - 07/14/26
    from
    $272Fare subject to changes
    Updated: 7 hours ago
    Round trip
    Economy

    Seattle (SEA)to

    Panama City (ECP)
    08/04/26 - 08/11/26
    from
    $403Fare subject to changes
    Updated: 8 hours ago
    Round trip
    Economy

    Kansas City (MCI)to

    Panama City (ECP)
    08/04/26 - 08/11/26
    from
    $311Fare subject to changes
    Updated: 8 hours ago
    Round trip
    Economy

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Find deals on flights to Panama City

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Dallas (DFW)to

Panama City (ECP)
07/22/26 - 07/29/26

Round trip

Economy

from
$257Fare subject to changes
Updated: 56 minutes ago

Charlotte (CLT)to

Panama City (ECP)
06/30/26 - 07/07/26

Round trip

Economy

from
$363Fare subject to changes
Updated: 9 hours ago

Washington, D.C. (DCA)to

Panama City (ECP)
11/11/26 - 11/18/26

Round trip

Economy

from
$287Fare subject to changes
Updated: 23 hours ago

Philadelphia (PHL)to

Panama City (ECP)
06/30/26 - 07/07/26

Round trip

Economy

from
$375Fare subject to changes
Updated: 2 hours ago

Chicago (ORD)to

Panama City (ECP)
08/05/26 - 08/12/26

Round trip

Economy

from
$347Fare subject to changes
Updated: 9 hours ago

Phoenix (PHX)to

Panama City (ECP)
06/23/26 - 06/30/26

Round trip

Economy

from
$397Fare subject to changes
Updated: 2 hours ago

*Fares displayed have been collected within the last 24hrs and may no longer be available at time of booking. Some fares listed may include one or more connections that are Basic Economy, which class is subject to additional terms and conditions. Modifying this information may result in a different fare. To find the most updated fare, please visit aa.com. Additional baggage fees and charges for optional products and services may apply.

Finding cheap flights to Panama City

Looking for lower fares on flights to Panama City? Here are a few ways to save.

  • Book early: Booking 1 to 3 months ahead can help you find lower fares
  • Be flexible with dates: Midweek travel, like Tuesdays and Wednesdays, can be more affordable
  • Travel during less busy periods: Flying outside peak travel times can help find lower fares and avoid crowds

Earn up to $200 back on your next American Airlines flight plus, 40,000 bonus miles. Offers vary elsewhere. Opens another site in a new window that may not meet accessibility guidelines.

Upgrade your flight with Main Cabin Extra

Make your trip more comfortable with Main Cabin Extra. Enjoy benefits like:

  • Extra legroom: More space with seats at the front of the Main Cabin or in exit rows.
  • Early boarding: Preferred Group 5 boarding allows easier access to overhead bins.
  • Complimentary drinks: Enjoy beer, wine and spirits on flights with full beverage service.

Discover how Main Cabin Extra can enhance your trip.

American Airlines flights to Panama City

Panama City routes with American Airlines